Northwestern University Feinberg School of Medicine

Skin Disease Research Center

H. William  Schnaper, MD

H. William Schnaper, MD

Vice Chair, Academic Affairs, Department of Pediatrics

Professor of Pediatrics (Kidney Diseases)

Focus of Work

Bio

William Schnaper received a B.A. in Philosophy from Yale University and his M.D. from the University of Maryland before serving as a resident and Chief Resident of Pediatrics at the Mount Sinai Hospital in New York. After two years in the National Health Service Corps he undertook a Fellowship in Pediatric Nephrology at St. Louis Children's Hospital/Washington University, subsequently joining the Faculty, where he treated children with kidney disease and studied the immunology of the nephrotic ...[Read full text]William Schnaper received a B.A. in Philosophy from Yale University and his M.D. from the University of Maryland before serving as a resident and Chief Resident of Pediatrics at the Mount Sinai Hospital in New York. After two years in the National Health Service Corps he undertook a Fellowship in Pediatric Nephrology at St. Louis Children's Hospital/Washington University, subsequently joining the Faculty, where he treated children with kidney disease and studied the immunology of the nephrotic syndrome. After four years in the extracellular matrix laboratory of Hynda Kleinman at the National Institute of Dental Research, he joined the Faculty in Pediatrics at Northwestern in 1994.[Shorten text]

Academic Focus

Dr. Schnaper has two major academic interests. His research interests involve fibrogenic mechanisms of progressive kidney disease. The Hayashida-Schnaper lab group studies the phenotypic regulation of fibrogenic responses. A variety of structural, metabolic and environmental factors influences whether renal cells respond to specific stimuli with fibrogenic activity. In particular, the laboratory studies how the molecule, Smad Anchor for Receptor Activation (SARA), maintains epithelial cell p...[Read full text]Dr. Schnaper has two major academic interests. His research interests involve fibrogenic mechanisms of progressive kidney disease. The Hayashida-Schnaper lab group studies the phenotypic regulation of fibrogenic responses. A variety of structural, metabolic and environmental factors influences whether renal cells respond to specific stimuli with fibrogenic activity. In particular, the laboratory studies how the molecule, Smad Anchor for Receptor Activation (SARA), maintains epithelial cell phenotype in a way that makes them resistant to fibrotic stimuli. For more information on the laboratory's activities, see the lab URL at http://www.pediatrics.northwestern.edu/research/labs/schnaper/index.html.

The second interest is career development. As Vice Chair of Pediatrics, Academic Affairs, Dr. Schnaper seeks to support the growth of academic faculty in various activities including Director of the Pediatric Physician-Scientist Training Program, Co-director of the Department of Pediatrics Office of Faculty Development and Program Director for the NUCATS Postdoctoral Training Program in Engineering and Pediatrics.[Shorten text]

Clinical Focus

Dr. Schnaper has studied the clinical manifestations of glomerular disease and the mechanisms by which kidney disease progresses to chronicity and ultimately the need for dialysis and transplantation. A series of events occurs by which (1) the renal response to injury is either inadequate or excessive; (2) a compensatory response by the kidney causes stress to renal structures; (3) adaptive/maladaptive responses occur, altering renal metabolism to cause further stress; and (4) the resulting cyc...[Read full text]Dr. Schnaper has studied the clinical manifestations of glomerular disease and the mechanisms by which kidney disease progresses to chronicity and ultimately the need for dialysis and transplantation. A series of events occurs by which (1) the renal response to injury is either inadequate or excessive; (2) a compensatory response by the kidney causes stress to renal structures; (3) adaptive/maladaptive responses occur, altering renal metabolism to cause further stress; and (4) the resulting cycle of injury and misdirected repair leads inexorably to renal failure.
For information regarding clinical pediatric nephrology at Lurie Children's Hospital, please see the URL at: https://www.luriechildrens.org/en-us/care-services/specialties-services/kidney-diseases/specialists/Pages/index.aspx[Shorten text]

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Education and Certification

  • MD: University of Maryland (1975)
  • Residency: Mt. Sinai Hospital-NY, Pediatrics (1978)
  • Fellowship: Saint Louis Children's Hospital, Pediatrics Nephrology (1982)
  • Board Certification: Pediatric Nephrology, Pediatrics