Northwestern University Feinberg School of Medicine

Skin Disease Research Center

Grants

Grants awarded to our membership:

Research Grant (Peng) 07/01/2014-05/30/2015

Midwest Eye Bank

"miR-107 enhances limbal epithelial stem cell numbers in culture: implication for more efficient ex vivo limbal epithelial culture transplantation"

Chicago Biomedical Consortium (Getsios) 07/01/2014-06/30/2015

Postdoctoral Research Grant

"Eph Receptor Binding Partners that Regulate Human Epidermal Stem Cell Fate"

This is an award granted to a postdoctoral researcher in my lab, Dr. Bethany Perez White, to identify novel Eph receptor binding partners that regulate keratinocyte stem cell fate using a novel proteomic discovery approach. As Dr. Perez White’s mentor, I serve as the PI on the grant.

R01 EY019463 (Lavker) 07/01/2014-06/30/2019

NIH/NEI

"The Role of MicroRNAs in Corneal Epithelial Homeostasis"

The long term goal of this project is to understand how microRNAs (miRNAs) function in regulating the corneal and limbal epithelia.

Career Development Award (Peng) 07/01/2014-06/30/2017

Dermatology Foundation

"Regulation of the Cell Cycle by MicroRNAs: Quiescence Versus Proliferation"

Abnormal proliferation is a key characteristic in many diseases, including chronic skin ulcer, psoriasis and squamous cell carcinoma. To better understand the regulation of proliferation, we propose to elucidate functions of a microRNA family on regulating cell cycle. Thus, knowledge from this study could have potential utility in the diseases with abnormal cell kinetics.

Yamagiwa-Yoshida Memorial International Cancer Study Grant (Lesovaya –awardee / Budunova – preceptor) 04/01/2014-07/31/2014

The UICC

"Current application status: Awarded"

Robert H. Lurie Comprehensive Cancer Center bridge funding, (Budunova) 01/01/2014-12/31/2014

Sponsor: Director’s Fund/Wendy Wills Gift

"Novel GR-targeted Therapy for Mantle Cell Lymphomas"

Total Cost: $ 20,000

R21 (John Varga) 08/02/2013-07/31/2015

DOD

"Targeting adiponectin signaling: Novel peptide therapy for scleroderma"

Research Grant (Peng) 07/01/2013-06/30/2014

Dermatology Foundation

"Growth factor signaling in keratinocytes is regulated by FIH-1: implication for wound healing"

Abnormal signaling of the epidermal growth factor receptor (EGFR) plays a central role in psoriasis, atopic dermatitis and squamous cell carcinoma. To better understand how this receptor is regulated, we will study the interaction of a novel enzyme complex with the EGFR. Knowledge from this study should result in the development of novel therapies for treating skin diseases associated with abnormal EGFR signaling. Current

Research Fellowship, M. Kavesh (Paller) 07/01/2013-06/30/2014

Howard Hughes Medical Institute

"Multiplexed Nanoflares for Predicting Chemotherapy Responses of Metastatic Melanomas"

RO1CA172669-01 (Pelling) 03/06/2013-02/28/2018

NIH/NCI

"Apigenin restores TSP-1 expression in UVB-irradiated keratinocytes"

The goal of this proposal is to investigate the mechanisms by which the bioflavonoid apigenin maintains levels of the anti-angiogenic factor Thrombospondin-1 in UVB-exposed epidermis.

IIN Seed Grant (Paller) 03/01/2013-02/28/2014

International Institute for Nanotechnology

"Spherical Nucleic Acids to Treat Psoriasis: Targeted Suppression of Cytokine Activation"

The project will perform critical research with a humanized mouse model with the goal of bringing the topical delivery of SNAs as a novel gene suppression therapy for psoriasis to the FDA for review and preclinical studies.

R01CA122151 (Green) 09/11/2012-07/31/2017

NIH/NCI

"Regulation of Desmosomal Cadherins in Oral Cancer"

The major goals of this proposal are to test the hypothesis that loss of desmoglein 1 during oral cancer progression results in elevated EGFR/Erk signaling and a consequent shift in the balance between

5RO1AR062110 (Getsios) 09/07/2012-08/31/2017

NIH/NIAMS

"EphA/Ephrin-A signaling in epidermal differentiation and disease"

Information from this project will lead to a better understanding of how a cell-cell communication pathway, termed the EphA/ephrin-A signaling axis, governs the differentiation of keratinocytes in [the human epidermis.

Foundation for Ichthyosis and Related Skin Types (Paller) 09/01/2012-08/31/2014

"Topical delivery of keratin 10 mutation-specific siRNA-gold nanoparticles for epidermolytic ichthyosis"

The aims of this investigation are to: a) Optimize the specific knockdown of the hot-spot KRT10 R156H/c.467G>A mutation in keratinocytes isolated from patients with EI using KRT10 siRNA Spherical nucleic acid-nanoparticle conjugates; and b) to suppress the KRT10 hot-spot mutation in a skin-humanized mouse model of epidermolytic ichthyosis.

BAA-NIAID-DAIT-NIHAI2009027 (Leung: Parent PI, Paller: Sub PI) 09/01/2012-06/30/2014

NIH/ NIAID (subcontract to Leung, PI)

"A Randomized Open Label Mechanistic Study in Atopic Dermatitis to Assess the Immunogenicity of Fluzone Intradermal and Intramuscular Vaccines (ADRN Fluzone)"

The purpose of the ADRN - Fluzone is to determine if the immune responses to immunization with flu vaccine are abnormal in atopic dermatitis, which may give us a clue as to why individuals with atopic dermatitis are more prone to bacterial and viral colonization/infection.

R01AR041836 (Green) 09/01/2012-08/31/2017

Function of desmoglein 1/pemphigus foliaceus antigen

The major goals of this project are to determine how desmogleins and desmocollins assemble into desmosomes of keratinocytes and to determine the function of desmoglein 1 in epidermal differentiation and morphogenesis.

Dermatology Foundation (Johnson) 07/01/2012-06/30/2014

Research Career Development Award

"Role of Cell Anchoring Desmosomal Proteins in the Epidermal Responses to UV Exposure"

The goal of this study, as modeled in Fig. 1A, is to test the hypothesis that desmosomal proteins help maintain epidermal homeostasis and protect against skin carcinogenesis following UV exposure through promoting differentiation and apoptosis and inhibiting cellular proliferation.

Women’s Health Career Development Award (Schlosser) 07/01/2012-05/30/2017

Dermatology Foundation

"Clinical and molecular characterization of lichen sclerosus as a model of vulvar epithelial fibrosis"

The goal of this project is to investigate how to best measure lichen sclerosus induced scarring and what molecules are involved and the effects of treatment on the scarring of lichen sclerosus.

5R01HL046849-22 (Muller, W.A.) 06/01/2012-05/31/2015

NIH/NHLBI

"Roles of Endothelial PECAM-1 and the LBRC in Leukocyte Transmigration"

The aims of this application are to investigate how PECAM and the LBRC regulate diapedesis, with special attention to the role of PECAM in LBRC function.

2RO1EY006769-24 (Lavker) 05/01/2012-04/30/2015

NIH/NEI

"Corneal Epithelial Stem Cells"

Information from this project will impact on our understanding of how the hydroxylase, “factor inhibiting hypoxia-inducible factor-1” (FIH-1) contributes to the maintenance of corneal epithelial stem cells. These studies will lead to a better comprehension of disorders of corneal epithelial differentiation, particularly:(i) dystrophies; (ii) dry eye; (iii) keratitis resulting from excessive glycogen depletion; and (iv) diabetic-induced keratopathies.

5R37 HL064774-1 (Muller, W.A.) 05/01/2012-04/30/2015

NIH/NHLBI

"Beyond PECAM: Mechanisms of Transendothelial Migration"

The long-term objectives of this research application is to better understand the cellular and molecular basis of the inflammatory response in order to develop better therapies to augment it in conditions where the host's immune response is compromised, and to inhibit it under conditions where the response is counterproductive, such as in inflammatory diseases like atherosclerosis, rheumatoid arthritis and other autoimmune diseases, septic shock, asthma, and transplant rejection.

1R01AR061497-01A1 (Radek) 05/01/2012-04/30/2017

NIH, NIAMS

"Linking Nicotinic Activation with Skin Innate Immunity and Atopic Dermatitis"

The objective of the proposed research is to identify the nAChR subtype(s) involved in AMP suppression in keratinocytes, evaluate the AMP profile altered by nAChR activation, and link this mechanism to the pathogenesis of Atopic Dermatitis (AD).

CCNE Alliance Challenge Grant (Paller) 04/01/2012-09/30/2013

Center of Cancer Nanotechnology Excellence (CCNE)

"PRINT-encapsulated hybrid siRNA-gold nanoparticles for metastatic melanoma"

The aim of this study is to develop multifunctional siRNA gold nanoparticles (siRNA-AuNPs) for targeting known genes involved in metastatic melanoma using a combinatorial in vitro approach and PRINT technology and to assess the ability of encapsulation of hybrid siRNA-AuNPs to increase duration of circulation and perform preliminary testing of the efficacy of the encapsulated siRNA-AuNPs.

1T32AR060710-01A1 (Lavker) 04/01/2012-03/31/2017

NIH/NIAMS

"Post Graduate Program in Cutaneous Biology"

This Post Graduate Training Program in Cutaneous Biology provides a means to develop academic dermatologists with a thorough grounding in both bench and translational research to serve as the next generation of academicians in dermatology and cutaneous biology. Roles: PI: Lavker, co-I: Paller

Research Grant (Godsel) 04/01/2012-03/31/2013

Skin Cancer Foundation

"The role of the desmosome protein, plakophilin 2, in cancer"

Aims for this grant include: (1) to determine the PKP2-regulated pathways that affect epithelial cell-substrate interactions and (2) to determine the effects of PKP2 loss on tumor cell invasion and metastasis. Current

R01AR060810-02 (Paller, Mirkin) 03/01/2012-02/28/2016

NIH/NIAMS

"Topical Delivery of siRNA Nanconjugates: Suppressing Epidermal Hyperplasia"

This proposal optimizes the size and charge of siRNA-Au NPs for cutaneous penetration after topical application, determines the mechanism of uptake, and evaluates the ability of siRNA-Au NPs targeting a point mutation in Ras to suppress its target in mouse skin and human skin equivalents.

R21AR062898-01 (Paller, Mirkin) 03/01/2012-02/28/2014

NIH/NIAMS

"siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healing"

The long-term goals of this project are to apply gene-suppressing topically-applied nanoparticles that block ganglioside biosynthesis as a new means to address the impaired wound healing in diabetics and to better understand how gangliosides impact KC proliferation and motility.

R21AR062898-01S1 (Paller, Mirkin) 03/01/2012-02/28/2014

NIH/NIAMS

"siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healing-Administrative Supplement"

This Administrative Minority Supplement provides support for the mentorship and training of Desmond Shipp , MD to address the parent R21long-term goals of applying gene-suppressing topically-applied nanoparticles that block ganglioside biosynthesis as a new means to address the impaired wound healing in diabetics. Dr. Shipp will also work to gain a better understand how gangliosides impact KC proliferation and motility.

IIN Seed Grant (Paller) 03/01/2012-08/31/2014

International Institute for Nanotechnology

"Targeting the Immune Activation in Psoriasis with Spherical Nucleic Acid Nanoparticles"

The long term objective of this project is to utilize nanotechnology to generate topically-applied targeted immunosuppression for psoriasis.

Research Grant (Getsios) 01/07/2012-06/30/2013

Illinois Society for the Prevention of Blindness

"EphA/ephrin-A signaling axis in normal and diabetic corneal epithelium"

The major goal of this project is to study the EphA2/ephrin-A1 signaling pathway using a human corneal epithelial equivalent culture model that mimics the hyperglycemic conditions of diabetes.

SP0017743 Dixon Translational Research Grants Initiative (Budunova) 01/01/2012-12/31/2012

Northwestern Memorial Foundation and NUCATS

"Off-label use of proteasome inhibitor Bortezomib in dermatology"

The proposal is focused on the off-label use of proteasome inhibitor anti-cancer drug Bortezomib for GR-targeted anti-inflammatory therapy in dermatology.

American Skin Association Research Scholar Award (Getsios) 01/01/2012-12/31/2012

"EphA2 as a molecular and therapeutic target in psoriasis"

This career development award provides funding to study the role of EphA2 in psoriasis. The objectives for this proposal are to measure the changes in Eph/ephrin family gene expression in psoriasis, examine the regulation of EphA2 by inflammatory cytokines in 3-D keratinocyte models and determine whether ephrin ligands can reduce EphA2 levels and increase keratinocyte differentiation upon cytokine exposure. These studies provide the basis for some of the preliminary data outlined in this proposal.

K99 AR060242 (Hamill) 09/15/2011-08/31/2012

NIH/NIAMS

"Functional analyses of a member of a novel family of laminin-related proteins"

RO1 AR054184 (Jones) 09/01/2011-08/31/2016

NIH/NIAMS

"Keratinocyte Migration and Wound Healing"

1R21AR061174-01A1 (Chandel-former SDRC P&F) 08/01/2011-04/30/2013

NIH/NIAMS

"Mitorchondrial ROS Regulate Skin and Hair Homeostasis"

This grant tests the hypothesis that mitochondrial generation of ROS is required for epidermal homeostasis and function by allowing for the propagation of signaling pathways required for maintenance of stem cell populations, growth factor signaling within the epidermis, and epidermal oxygen sensation. Co-I: Lavker

Melanoma Research Award - Translational Research (García-Añoveros-former SDRC P&F) 06/01/2011-05/31/2012

Harry J. Lloyd Charitable Trust

"MCOLN3 in Melanoma"

The main goal of this grant is to test for the role of the Mcoln3 gene - which maps to a chromosomal region of melanoma susceptibility, is expressed in melanocytes and encodes the TRPML3 ion channel - in melanomagenesis.

NU-NSEC/NU-PSOC (Mirkin: Parent PI, Paller: Seed Grant PI) 06/01/2011-05/31/2012

Nanoscale Science and Engineering Center and Physical Sciences-Oncology Center Pilot Project

"Gadolinium Tagged siRNA Nanoparticles for In Vivo Imaging towards Melanoma Therapy"

This study evaluates whether a gadolinium tag can be added to siRNA-gold nanoparticles for real-time MRI tracking of siRNA-nanoparticles after topical delivery.

R37 AR043380 (Green) 04/01/2011-03/31/2016

NIH/NIAMS

"Desmoplakin Assembly and Function in Epidermis"

The goals of this proposal are to determine how desmoplakin and its associated armadillo proteins in the plakophilin (PKP) family act as scaffolds to localize and harness the activities of signaling mediators required for junction assembly and epidermal differentiation, and how DP/PKP deficiency and mutations affecting DPPKP interactions contribute to disease pathogenesis by interfering with their structural and signaling functions.

5R01EY019463-02 (Lavker) 06/01/2010-05/31/2014

NIH/NEI

"The Role of MicroRNAs in Corneal Epithelial Homeostasis"

The long term goal of this project is to understand how microRNAs (miRNAs) function in regulating the corneal and limbal epithelia.

U54CA119341 (Mirkin, PI of CCNE) 04/01/2010-10/30/2011

NIH/NCI/CCNE Seed Award

"Targeting Ras activation with oligonucleotide-nanoconstructs"

This seed grant supports the preliminary development of siRNA-gold nanoparticles directed against a Ras mutation (G12V) at a point mutation level. This is a seed grant to support the preliminary studies of this proposal.

NCCR ULI RR025741 (Greenland, PI of parent grant) 03/01/2010-02/28/2011

NIH (NUCATS Pilot Award)

"Transdermal delivery of siRNA nanoconjugates to suppress metastatic melanoma"

This pilot award supports the preliminary investigation of the efficacy and safety of siRNA-gold nanoparticles directed against activated melanoma signaling pathways to suppress the growth and metastasis of melanoma in a mouse model.

R01HL068033 (Volpert) 04/01/2005-03/31/2010

"Regulation of angiogenic balance by thrombospondin-1 MicroRNA in control of angiogenesis"

Grants Form

Complete and submit our grants form if your pending or funded grant uses a SDRC Core facility.